What is Research

Research

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Scientific Research involves performing a methodical study in order to prove a theory or answer a specific question. It is carried out in Universities, Laboratories and Hospitals across Ireland by healthcare professionals and scientists.  Examples of  questions that have been addressed by research into diabetes are;-

  • Will good glucose control delay retinopathy cataracts, neuropathy etc ?
  • What are the optimal treatment targets for glucose, blood pressure and cholesterol in type 2 diabetes?
  • How does drug “x” compare against weight-loss, dietary change and exercise?

Research involves gathering numbers, statistics, opinions, motivations and observations to answer these kind of questions.

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How will you know “health claims” are true?

Research becomes valid information when it is shared with peers, discussed, disputed and tested by other scientists. Research teams look to publish their findings in reputable medical journals. Published research brings recognition that helps scientists raise funds to do more research.

 Types of Research

There are two types of research: quantitative research which deals with numbers and qualitative which deals with attitudes, opinion and behaviour.

Quantitative Research is used to quantify a problem by way of generating numerical data or data that can be transformed into usable statistics. It is used to quantify attitudes, opinions, behaviours, and other defined variables  and generalise results from a larger sample population. Quantitative Research uses measurable data to formulate facts and uncover patterns in research. Quantitative data collection methods are very structured and data collection methods include various forms of surveys – online surveys, paper surveys, face-to-face and telephone  interviews, online polls, and systematic observations.

Qualitative Research is primarily exploratory research. It is used to gain an understanding of underlying reasons, opinions, and motivations to provide insights into a problem or to further develop ideas or hypotheses for further  research. Qualitative Research is also used to uncover trends in thought and opinions. Common data collection methods include focus groups (group discussions), individual interviews, and participation/observations. The sample size is typically small, and respondents are selected to fulfil a given quota.

If you would like to read more on research terminology, visit IPPOSI clinical trails . Please note that clinicaltrials.ie is a public awareness initiative created by IPPOSI (Irish Platform for Patient Organisations, Science & Industry)

 Clinical Trials

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Research on medications, devices and treatments has to undergo animal and/or human clinical trials to protect the health of the population.


FAKE NEW 2What is a breakthrough in research?

Many new advances in diabetes management are heralded as a dramatic breakthrough by the media whilst in reality, the study is still ongoing with potential side-effects and effectiveness  being carefully monitored.  When you hear of a breakthrough in diabetes, visit the Diabetes Ireland website for official news releases and interpretation of new findings.

Phases of Clinical Trials

Before drugs and certain treatments come onto the public market, they must undergo clinical trials. There are 3 to 4 phases that a company has to undertake. The table below gives you an idea of how much work is involved in this process.
  Phase 1 Phase 2Phase 3Phase 4
Trial Duration4 years18 months2 to 15+ years2 -10 years
Number of People Involved10 to 20Hundreds of peopleThousands of peopleA selection of patients using the device/medication/
treatment
Health Status of ParticipantsHealthy peoplePeople diagnosed with the conditionPeople diagnosed with the conditionPeople diagnosed with the disease/condition using the drug/treatment as prescribed
What happens at each PhaseSafety testSeveral trials to test the safety and effectiveness of the product/interventionExpand trials to all ages with all stages of the condition. Possibly randomised controlled trials using placebo and the real treatment. Application for license to market. Trial results usually appear in media at this stageTrials continue while treatment is publicly available for safety surveillance & drug technical support.

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Clinical Trials & Diabetes

The biggest practical questions in the management of diabetes are first, how to avoid it? And second, how to assure the best possible future for those who develop the condition?  Landmark Clinical Trials are DCCT/EDIC. (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) in Type 1 Diabetes and UKPDS (United Kingdom Prospective Diabetes Study) in Type 2 Diabetes.

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  • Diabetes Ireland Research Alliance

    The Diabetes Ireland Research Alliance (DIRA) was set up in 2008 as a subsidiary of Diabetes Ireland, the national charity supporting people with diabetes in Ireland. DIRA has the specific aim of promoting, supporting and funding research related to the causes, prevention and cure of diabetes. The Alliance primarily funds high quality diabetes research projects in... View Article

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