Exploring Novel Biomarkers of Brain Health in Diabetes (ENBIND)

Name of Study


Exploring Novel Biomarkers of Brain Health in Diabetes (ENBIND)


Purpose of Study

Midlife type 2 diabetes is a risk factor for the development of dementia in later life. In this study we aim to investigate the link between diabetes and memory problems in middle-aged people who have a diagnosis of diabetes and that of non-diabetics. The study focuses on memory, mood, gait speed and blood inflammatory markers.



Type of Study (observational/exploratory etc.)

Longitudinal study with follow up in 3-5 years.


Are you recruiting participants for this trial?




Geographical location of study 


Tallaght University Hospital


Who can take part?

Inclusion Criteria: (1) male and female, aged 40-65 years; diagnosis of T2DM, without peripheral neuropathy or peripheral arterrial disease. Exclusion Criteria: (i) pregnancy, (ii) established diagnosis of dementia and/or cognitive impairment, (iii) severe kidney disease, (iv) active diagnosis of depression within the last 6 months, (v) unstable angina, previous myocardial infarction, intermittent claudication, (vi) use of psychotropic medication, (vii) parkinsonism, (viii) previous knee or hip replacement, (ix) previous neurosurgery, (x) previous stroke, (xi) previous traumatic brain injury.


What will the participants be asked to do?


The study involves assessment of walking (gait), memory, mood and a clinical assessment, including a blood test. Firstly, there will be a short medical history, a mood and memory assessment using standard assessment tools. Following this is an iPad assessment involving pattern recognition and memory exercises. Then a short walking task measuring speed and ability to perform simple tasks simultaneously.



Recruitment Start Date




Recruitment Finish Date




Study Duration

2 years



This study is funded by:

The Meath Foundation


For further information contact:


Dr Louise McKenna




087 7700194



[email protected]